항응고성의 3-(N-Arylamino)-1,4-Naphthoquinone 유도체 합성(II)

• 영문명: Synthesis of Anticoagulant 3-(N-Arylamino)-1,4-Naphthoquinones(II)
• 발행기관: 대한약학회
• 저자명: 유충규(Chung Kyu Ryu) 오재돈(Jae Don Oh) 서명은(Myung Eun Suh)
• 간행물 정보: 『약학회지』제33권 제5호 (1989년), 273~279쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.10.28

영문 초록

2,3-Dichloro-1,4-naphthoquinone was reacted with o-fluoroaniline, p-sulfadiazine, p-acetoanline, N,N-dimethyl-1,4-phenylenediamine as a nucleophilic substitution to form 2-chloro-3-(N-arylamino)-1,4-naphthoquinones (l.-6.) in good yield. 2,3-Dibromo-1,4-naphthoquinone was also reacted with o-fluoroaniline, m-aminobenzoic acid, m-chloroaniline, morpholine, p-acetoaniline, N,N-dimethyl-1,4-phenylenediamine as a nucleophilic substitution to give 2-bromo-3-(N-arylamino)-1,4-naphthoquinones (7.-12.). These new compounds are expected to have a biological activities such as anticoagulant, cytotoxic.

키워드

2-Halogeno-1,4-napthoquinone anticoagulant cytotoxic substitution aromatic amine