아미노산 Phenylthiohydantoin 유도체를 키랄 고정상으로 한 GC에 의한 아미노산 광학 이성질체의 상호분리

• 영문명: Separation of Amino Acid Enantiomers by Gas Chromatogaphy on Phenylthiohydantoin Derivatives as Chiral Stationary Phases
• 발행기관: 대한약학회
• 저자명: 박만기(Man Ki Park) 양정선(Jeong Seen Yang) 고창범(Chang Bum Ko) 이미영(Mi Yung Lee)
• 간행물 정보: 『약학회지』제32권 제3호 (1988년), 170~176쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.06.29

영문 초록

The resolution of five amino acids derivatives by gas chromatography on phenylthiohydantoin derivatives as chiral stastionary phase was investigated. (S)-5-isopropyl, isobutyl, (sec)-butyl and benzoyl derivatives of N3-phenyl-2-thiohydantoin were synthesized from L-valine, L-leucine, L-isoleucine and L-phenylalanine, respectively. The phases were employed at several column temperatures (140oC-210oC). The separation factors were compared with each stationary phase with varying R groups. The possible mechanism of chiral recognition was investigated by NMR technique.