1,4-Dihydropyridine 유도체들의 합성 및 혈압강하 효과

• 영문명: Synthesis and Cardiovascular Activities of 1,4-Dihydropyridine Derivatives
• 발행기관: 대한약학회
• 저자명: 심영기(Young Key Shim) 전재상(Jae Sang Chun) 김완주(Wan Joo Kim)
• 간행물 정보: 『약학회지』제32권 제3호 (1988년), 157~163쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.06.29

영문 초록

4-Aryl-1,4-dihydropyridines(DHP) derived from Hantsch type condensation of aromatic aldehydes with aminocrotonates and acetoacetic esters are studied as calcium channel blocking drugs. New DHP derivatives containing alkenyl ester show fairly good cardiovascular activity in mice. Preparation of the DHP derivatives and their major biological activity are presented along with their physical data.