화학요법제합성연구 N-(Substituted-2-benzothazolyl) Acid Amided의 합성 및 그 항균성과 항인결핵성

• 영문명: Synthetic Studies on Chemotherapeutic Agents. I. Synthesis and their Antimicrobial and Antitubercular Activity of N-(6-Substituted-2-benzothiazolyl) Acid Amides
• 발행기관: 대한약학회
• 저자명: 조윤성(Yun Sung Chough) 김기원(Kee Won Kim)
• 간행물 정보: 『약학회지』제15권 제3&4호 (1971년), 83~86쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1971.12.31

영문 초록

Nine novel compounds, namely, 2-(p-aminobenzenesulfonamido)-6-sulfamylbenzothiozole, 2-benzamido-6-sulamylbenzothiazole, 2-(p-toluenesulfonamido)-6-sulfamylbenzothiazole, 2-(3, 5-dinitrobenzamido)-6-sulfamylbenzothiazole, 2-benzamido-6-nitrobenzothiazole, 2-(p-toluene-sulfonamido)-6-nitrobenzothiazole, 2-(3, 5-dinitrobenzamido)-6-nitrobenzothiazole, 2-(p-toluenesulfonamido)-6-chlorobenzothiazole, 2-(3, 5-dinitrobenzamido)-6-chlorobenzothiazole were synthesized and evaluated for their in vitro antimicrobial activity against Staphylococcus aureus wood 46, beta-Streptococcus S86, Escherichia coli and antitubercular activity against Mycobacterium tuberculosis H37Rv. 2-(p-Toluenesulfonamido)-6-chlorobenzothiazole showed antimicrobial activity at 25mcg/ml against beta-Streptococcus S/86, 2-(3,5-Dinitrobenzamido)-6-sulfamylbenzothiazole was active at 5mcg/ml and 2-(3,5-dinitrobenzamido)-6-nitrobenzothiazole was considerably active at lmcg/ml against Mycobacterium tuberculosis H37Rv.