Sandalwood Essential Oil의 iNOS 발현과 염증성사이토카인의 생성에 미치는 영향

• 영문명: Effects of Sandalwood Essential Oil on the iNOS Expression and Proinflammatory Cytokine Production
• 발행기관: 대한약학회
• 저자명: 박정숙 정숙희
• 간행물 정보: 『약학회지』제57권 제1호 (2013년), 70~75쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.02.28

영문 초록

The present study was designed to determine the effect of the Sandalwood Essential Oil (Santalum album) on pro-inflammatory factors such as NO, iNOS expression and IL-1β, IL-6, TNF-α in lipopolysaccharide (LPS) - stimulated RAW264.7 macrophages cells. The cell toxicity was determined by MTS assay. To evaluate of anti-inflammatory effect of Sandalwood Essential Oil, amount of NO was measured using the NO detection kit and the iNOS expression was measured by western blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR). And proinflammatory cytokines were measured by ELISA kit. As a result, Sandalwood Essential Oil reduced NO, iNOS expression and IL-1β, IL-6, TNF- α production without cytotoxicity. Our results suggest that the Sandalwood Essential Oil may have an anti-inflammatory property through suppressing inflammatory mediator productions and appears to be useful as an anti-inflammatory oil.

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키워드

sandalwood essential oil iNOS IL-1β IL-6 TNF-α