간질을 동반하는 신경질환에서 염증반응의 역할

• 영문명: Role of Inflammation in Neurological Disorders Associated with Epilepsy
• 발행기관: 대한소아신경학회
• 저자명: 최지은(Ji Eun Choi) 이란(Ran Lee)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제16권 제2호, 105~113쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2008.11.30

영문 초록

It is well known that inflammation has a important role in the pathogenesis of diverse neurodegenerative disorders. There are also growing numbers of evidences that inflammation is involved in the pathogenesis of epilepsy. For many decades, implication of brain inflammation to epilepsy has been suggested by the effectiveness of anti-inflammatory medications in treating intractable pediatric epilepsies, increased incidence of spontaneous epilepsy in autoimmune disorders, and increased level of proinflammatory cytokines in the blood of patients who experienced recent seizures. Recently, activation of microglia and astrocytes and production of proinflammatory cytokines and related molecules have been reported in surgically resected brain tissue from epilepsy patients as well as from experimental animals of epilepsy models. These evidences suggest that inflammatory process may contribute to epileptogenesis and to neuronal injury after seizures. Thus we provide a review of current understandings about implication of brain inflammation to diverse neurological disorders associated with epilepsy.

목차

서론

1. 간질을 동반하는 비감염성 신경질환

2. 소아 난치성 간질에서 항염증치료 효과

3. 열성경련의 발병기전에서 염증반응의 역할

4. 경련에 의해 유발되는 뇌의 염증반응

결론

References

키워드

Epilepsy Cytokine Immunity Microglia Astrocytes Steroid