Effect of Goat Meat on Muscle Atrophy Induced by Dexamethasone in Mice

• 발행기관: 한국축산식품학회
• 저자명: Jisun Lee Jei Oh Joohyun Kang Yohan Yoon
• 간행물 정보: 『Food Science of Animal Resources』제45권 제4호, 1062~1077쪽, 전체 16쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.07.15

국문 초록

This study investigated if the intake of goat meat affects muscle atrophy and changes gut microbiota in animal models. Muscle atrophy-induced mice (C57BL/6N; 5- week-old) by dexamethasone were treated with a standard chow diet (DEX) and goat meat (DEX+G) for 18 d. Muscle atrophy-uninduced mice were treated with the standard chow diet (CON). The relative muscle mass (gastrocnemius, soleus, and quadriceps femoris) to the body weight of the mice, levels of serum biochemical markers, expression levels of muscle atrophy-related proteins, and cross-sectional area (CSA) of muscle fibers were measured in the mice. The gut microbiota was also analyzed. The relative mass of only the gastrocnemius muscle was slightly higher in the DEX+G than in the DEX. However, improvement related to muscle mass was not observed in serum biochemical markers. Of the three examined proteins in gastrocnemius muscle, muscle RING finger protein 1 (MuRF1) and growth differentiation factor 8 (GDF-8) expression levels were lower in the DEX+G than in the DEX group. The average CSA of gastrocnemius muscle fiber was slightly higher in the DEX+G group than in the DEX group, but it was lower in the DEX+G group than in the CON group. The goat meat treatment changed the composition of some gut bacteria in muscle atrophy-induced mice. In summary, goat meat intake might have a slight effect on improving gastrocnemius muscle mass and its CSA only, not in the other muscles, and the intake might change gut microbiota. The current findings are only from a mouse model, and they indicate that goat meat treatment might have only a slight effect on limited factors. Therefore, further research is necessary to assess the more apparent effect of goat meat on muscle atrophy, especailly in humans.

목차

Introduction

Materials and Methods

Results and Discussion

Conclusion

References

키워드

muscle atrophy goat meat gut microbiota skeletal muscle