Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Mohamed Ali Metwally El-Yamani Ibrahim El-Zawahry Maher Amer Ali Diaa Farrag Ibrahim Shereen Ahmed Sabry Omnia Mohamed Sarhan
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제28권 제3호, 275~284쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.05.01

국문 초록

Worldwide, cardiovascular disease is the main cause of death, which ac-cordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to con-trol high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, be-cause of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181–0.72) and (–13.4 to –6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters us-ing triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formula-tions is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Bioavailability Cardiovascular disease Poloxamer Statins