Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients

• 발행기관: 대한생리학회-대한약리학회
• 저자명: John Rajan Girwar Singh Gaur Karthik Shanmugavel Adinarayanan S
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제28권 제3호, 253~264쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.05.01

국문 초록

Chronic neuropathic pain (CNP) is a complex condition often arising from neural maladaptation after nerve injury. Understanding CNP complications involves the intricate interplay between brain-heart dynamics, assessed through quantitative electroencephalogram (qEEG) and heart rate variability (HRV). However, insights into their interaction in chronic pain are limited. Resting EEG and simultaneous electro-cardiogram (lead II) of the participants were recorded for qEEG and HRV analysis. Correlations between HRV and qEEG parameters were calculated and compared with age, sex, and body mass index (BMI)-matched controls. CNP patients showed reduced HRV and significant increases in qEEG power spectral densities within delta, theta, and beta frequency ranges. A positive correlation was found between low fre-quency/high frequency (LF/HF) ratio in HRV analysis and theta, alpha, and beta fre-quency bands in qEEG among CNP patients. However, no significant correlation was observed between parasympathetic indices and theta, beta bands in qEEG within CNP group, unlike age, sex, and BMI-matched healthy controls. CNP patients display significant HRV reductions and distinctive qEEG patterns. While healthy controls ex-hibit significant correlations between parasympathetic HRV parameters and qEEG spectral densities, these relationships are diminished or absent in CNP individuals. LF/HF ratio, reflecting sympathovagal balance, correlates significantly with qEEG frequency bands (theta, alpha, beta), illuminating autonomic dysregulation in CNP. These findings emphasize the intricate brain-heart interplay in chronic pain, warrant-ing further exploration.

목차

INTRODUCTION

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DISCUSSION

키워드

Autonomic nervous system Chronic pain Electroencephalography Heart rate variability Neuropathic pain