Role of neuroinflammation in neuropathic pain: a narrative review

• 영문명: Role of neuroinflammation in neuropathic pain: a narrative review
• 발행기관: 조선대학교 의학연구원
• 저자명: Chung Woosuk Jung Ki Tae
• 간행물 정보: 『Medical Biological Science and Engineering』제6권 제2호, 57~62쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.07.31

영문 초록

Neuropathic pain, which can develop throughout the somatic sensory nervous system, occurs because of lesions or diseases in the somatosensory system, from the nerve terminal to the peripheral nerve of the nerve root, spinal cord, and brain. Inflammation plays a crucial role in the pathogenesis of neuropathic pain. Various pathological conditions of the nervous system can cause excessive neuroinflammation. Activation of inflammatory cells and subsequent inflammatory mediators results in neuropathic pain. Therefore, the modulation of neuroinflammation may be an option for treating and preventing neuropathic pain. Autophagic phagocytosis is related to the regulation of proinflammatory cytokine activity and the management of neuropathic pain. However, the complex interactions between cellular responses and inflammatory mediators in neuroinflammatory processes remain unclear. This short review discusses the roles of inflammation in the development and modulation of neuropathic pain.

목차

INTRODUCTION

GENERAL COURSE OF INFLAMMATION

THE ROLE OF INFLAMMATION IN THE NEUROPATHIC PAIN DEVELOPMENT

ROLE OF AUTOPHAGY IN THE NEUROPATHIC PAIN DEVELOPMENT

CONCLUSION

CONFLICT OF INTEREST

REFERENCES

키워드

Autophagy Immune response Inflammation Neuralgia Pain