학술논문
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Seul Gi Kim Jin Young Sung Jae-Ryong Kim Hyoung Chul Choi
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제24권 제1호, 69~79쪽, 전체 11쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2020.01.31
4,120원
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국문 초록
영문 초록
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance to apoptosis. As a flavonoid, quercetin induces apoptosis in various cells. Accordingly, we investigated the relationship between quercetin-induced apoptosis and the inhibition of cellular senescence, and determined the mechanism of oxidative stress-induced vascular smooth muscle cell (VSMC) senescence. In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescenceassociated β-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways. Along with senescence, expression of the antiapoptotic protein Bcl-2 was observed to increase and the levels of proteins related to the apoptosis pathway were observed to decrease. Quercetin induced apoptosis through the activation of AMP-activated protein kinase. This action led to the alleviation of oxidative stress-induced VSMC senescence. Furthermore, the inhibition of AMPK activation with compound C and siRNA inhibited apoptosis and aggravated VSMC senescence by reversing p53-p21 and p16 pathways. These results suggest that senescent VSMCs are resistant to apoptosis and quercetin-induced apoptosis attenuated the oxidative stress-induced senescence through activation of AMPK.
Therefore, induction of apoptosis by polyphenols such as quercetin may be worthy of attention for its anti-aging effects.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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