Ephedrine 및 Epinephrine 의 작용(作用)에 미치는 Pyrogallol 의 영향(影響)

• 영문명: The Effect of Pyrogallol on the Pharmacological Action of Ephedrine and Epinephrine
• 발행기관: 대한약리학회
• 저자명: 임주택(Lim, Zoo-Taek)
• 간행물 정보: 『대한약리학잡지』제4권 제1호, 41~44쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1968.12.31

영문 초록

Pyrogallol is recently known to be a inhibitor of catechol-o-methyl transferase (COMT) and increase the action of epinephrine on the isolated rabbit atria. In this experiment, the author attempated to investigate the influence of pyrogallol on the effect of ephedrine and epinephrine on the blood pressure of the rabbit and isolated atria and excised intestine of the rabbit. The results obtained were summarized as follows; 1. Pyrogallol tends to increase the blood pressure and respiration of the rabbit. But it has no significant effect on the excised rabbit atria and intestine. 2. The effect of ephedrine on the blood pressure and respiration, isolated atria and excised intestine of the rabbit were not influenced by the pretreatment with pyrogallol. 3. The effect of epinephrine on the blood pressure and isolated atria of the rabbit is potentiated with pyrogallol pretreatment.