창출(蒼朮) Alkaloid 가 Schedule Controlled Behavior 에 미치는 영향(影響)

• 영문명: The Effect of Atractylis Alkaloid on Schedule-Controlled Behavior
• 발행기관: 대한약리학회
• 저자명: 홍사악(Hong, Sa-Ack) 문동연(Moon, Dong-Yeon)
• 간행물 정보: 『대한약리학잡지』제4권 제1호, 33~36쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1968.12.31

영문 초록

The effect on schedule controlled behavior and toxicity of Atractylis alkaloid was investigated in the pigeons which were trained on a multiple fixed-ratio fixed-interval schedule of food presentation. Atractylis alkaloid decreased the rate of responding during both the fixed-interval and fixed ratio component of the schedule at 10 mg/kg. Further depression occurred at 30 mg/kg. This flat dose-response curve for depression of conditioned behavior was typical of tranquilizers. Conclusively it was suspected that Atractylis alkaloid had major tranquilizing activity.