The Action of Acetylcholine on the End-Plate Potential

• 영문명: The Action of Acetylcholine on the End-Plate Potential
• 발행기관: 대한생리학회
• 저자명: Koh, Il-Sup
• 간행물 정보: 『대한생리학회지』제9권 제2호, 41~48쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1975.12.31

영문 초록

The failure of the action potential at the end-plate membrane to reach the sodium equilibrium potential is due to the stimulating action of acetylcholine on Na⁺-K⁺ pump. This action of acetylcholine causes an enormous increase in the K⁺ transport rate. The quantitative amount of potassium ions in the inside of the end-plate membrane prevented the permeability of sodium ions during the depolarization phase of the action potential. It would favor the changes in the shape of action potential by acetylcholine which are always toward a fixed potential slightly below the zero line. The increased Na⁺-K⁺ pump activity by acetylcholine is responsible for the hypopolarization of membrane. This reduces the membrane resistance of the end-plate during transmitter activity.