Kanamycin 및 Kanendomycin이 인공 stearic acid 단분자막에 미치는 영향

• 영문명: Effects of Kanendomycin, Kanamycin on Stearic Acid Monolayer
• 발행기관: 대한생리학회
• 저자명: 이승일(Lee, Syng-Il) 강두희(Kang, Doo-Hee)
• 간행물 정보: 『대한생리학회지』제9권 제2호, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1975.12.31

영문 초록

It has been reported that kanamycin lowers osmotic fragility and mechanical fragility by ultrasonification of human red cells. In the present study, we therefore investigated effects of Ca⁺⁺, kanendomycin and kanamycin on stearic acid monolayer using a langmuir trough and found fellowing results 1) Ca⁺⁺ added to the subphase condensed stearic acid monolayer, confirming earlier reports. 2) Likewise, kanendomycin and kanamycin condensed the stearic acid monolayer, the effects being dose dependent. The possible modes of action of kanamycin and kanendomycin on biological membrane were discussed and compared with those of Ca⁺⁺ and local anesthetics