세로토닌 수송체 조절부위 다형태와 청소년 재소자들의 충동성 및 공격성과의 연합연구

• 영문명: An Association Study of the Impulsiveness and Aggressiveness in Adolescent Prisoners with Serotonin Transporter Gene Promoter Region Polymorphism
• 발행기관: 대한신경정신의학회
• 저자명: 이종훈 김홍태 조근호
• 간행물 정보: 『신경정신의학』제43권 제2호, 183~188쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.03.30

영문 초록

Objectives：This study was carried out to explore the relationship between the impulsiveness and aggressiveness in adolescent prisoners and a polymorphism of the promoter region of the 5-HTT gene (5HTTLPR). Methods：198 adolescent prisoner volunleers and 68 male medical students as a normal control group were included in this study. The characteristics of adolescent prisoners and control subjects were assessed by using Barratt Impulsiveness Scale and Achenbach’s Child Behavior Checklist (CBCL). Genotypes of 5-HTTLPR were analysed with the primers flanking the regulatory region from genomic DNA. Results：Adolescent prisoners were significantly more aggressive (t=4.780, df=248, p<0.001), impulsive (t=5.220, df= 248, p<0.001), and delinquent (t=12.299, df=173.554, p<0.001) than control group. There were no statistically significant differences in genotype frequencies of 5-HTT between adolescent prisoners and control group (χ2=2.378, df=6, p=0.882). There were no statistically significant differences in allelic frequencies of 5-HTT between adolescent prisoners and control group (χ2=2.027, df=4, p=0.731). Conclusion：In view of the negative results in the association of the promoter region polymorphism of serotonin transporter and the characteristics of adolescent prisoner, the promoter region polymorphism dose not appear to be a candidate gene for the characteristics of adolescent prisoner group. Further systematic researches including varying variables of phenotype would be required.

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REFERENCES

키워드

Serotonin transporter Impulsiveness Aggressiveness Polymorphism Adolescent