초경 시작 시기가 여성 정신분열병 환자의 병의 경과에 미치는 영향

• 영문명: Impact of Age at Onset of Menarche on Subsequent Courses in Women with Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 김진훈 윤선욱 배명지 임선진 정은기 장동원
• 간행물 정보: 『신경정신의학』제44권 제5호, 576~582쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.09.30

영문 초록

Objectives：The protective effects of estrogen against the development of schizophrenia have been investigated in various perspectives. Previous studies showed patients with earlier age of menarche had later onset of schizophrenia and less frequent admissions. This study was performed to evaluate the effect of the age of menarche on subsequent courses including hospitalizations, suicidal attempts, physical harm to others, and psychotic symptoms in women with schizophrenia. Methods：Self-report menarche age, onset of psychotic symptoms, and clinical status were collected in a sample of 108 premenopausal women with the diagnosis of schizophrenia. Results：There was significant correlation between the age of menarche and the frequency of admissions (r=.321, p=.006). Also, patients with history of physical harms to others showed later age of menarche than those without (t=2.025, df= 106, p=.045). Conclusion：In women with schizophrenia, the age of onset of menarche affects subsequent courses indicated by frequency of admissions and violent behaviors. It is suggested that identifying the age of menarche might be helpful to predict the courses in women with schizophrenia. Further investigations regarding the relationship between estrogen and the courses of schizophrenia in women are needed

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키워드

Schizophrenia Menarche Estrogen Women Course Suicidal attempt Violent behavior Admission