일 대학병원에 입원하는 알코올 의존 환자에서 동반되는 베르니케 뇌병증의 선별 및 치료

• 영문명: Screening and Treating Wernicke’s Encephalopathy among Alcoholic Patients in a University Hospital
• 발행기관: 대한신경정신의학회
• 저자명: 이서정 이수영 하라연 김어수 정영철 남궁기
• 간행물 정보: 『신경정신의학』제50권 제4호, 323~328쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2011.07.30

영문 초록

Objectives The purpose of this study was to investigate the prevalence and clinical characteristics of Wernicke’s encephalopathy (WE) patients in alcoholics and to evaluate the utility of Caine’s criteria as a screening test. Methods We made an admission note including Caine’s criteria and applied it to patients who were admitted to an alcohol treatment unit. Demographic, clinical, and laboratory data were collected on 204 alcoholics. Our alcoholics who met more than one of Caine’s criteria were considered at risk for WE and were given high-dose thiamine IV therapy. Results WE was diagnosed in 15.2% of the alcoholic patients. Age and head trauma history were risk factors of WE. The sensitivity of Caine’s criteria was 97% and specificity was 54%. High-dose thiamine IV therapy appeared to be a safe and cost-effective method to prevent the serious complications of WE. ConclusionZZCaine’s criteria is useful as a screening test for WE among alcoholic patients. High-dose thiamine IV therapy is cost-effective for alcoholic patients who are considered to be at risk for WE.

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키워드

Wernicke encephalopathy Caine’s criteria Alcohol dependence Thiamine deficiency