학술논문
Revitalizing the neuronal powerhouse: therapeutic approaches for mitochondrial repair in neural dysfunction
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- 영문명
- 발행기관
- 대한신경모니터링학회
- 저자명
- Celine Abueva
- 간행물 정보
- 『Journal of Neuromonitoring & Neurophysiology』Vol.5 No.2, 61~74쪽, 전체 14쪽
- 주제분류
- 의약학 > 일반외과학
- 파일형태
- 발행일자
- 2025.11.30
4,480원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
Mitochondrial dysfunction is a significant contributor to neurodegeneration, impacting neuronal health and function across various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. This review explores therapeutic strategies focused on mitochondrial rejuvenation, encompassing small molecule and metabolic modulation, mitochondrial augmentation therapies, and neuromodulatory approaches. Promising interventions include nicotinamide adenine dinucleotide boosters, antioxidants, and mitochondrial biogenesis activators that enhance energy metabolism and reduce oxidative stress. Stem cell-mediated mitochondrial transfer, isolated mitochondrial transplantation, and extracellular vesicle-based delivery represent innovative augmentation therapies aimed at restoring mitochondrial function. Additionally, red and near-infrared photobiomodulation alongside electrical and chemical neuromodulation is examined for its potential to enhance mitochondrial efficacy safely. The review also discusses translational barriers, including delivery challenges, timing of interventions, compatibility in donor-host integration, and the need for standardized functional assessments. Finally, clinical prospects highlight the importance of combining mitochondrial therapies with regenerative strategies and using engineering approaches for targeted and durable restoration of mitochondrial function, paving the way for enhanced outcomes in aging and neurodegenerative diseases.
영문 초록
목차
Introduction
Mechanisms of Mitochondrial Failure in Neurons
Therapeutic Strategies for Mitochondrial Rejuvenation
Translational Barriers and Opportunities
Clinical Prospects and Directions
Conclusion
Funding
Conflict of Interest
Data Availability
Author Contributions
ORCID
References
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참고문헌
관련논문
의약학 > 일반외과학분야 NEW
- Neural risks, protection, and monitoring in endoscopic sinus surgery: anatomy, imaging, outcomes, and emerging AI tools
- Journal of Neuromonitoring & Neurophysiology Vol.5 No.2 Contents
- Illuminating minds vs. chemical control: a comprehensive comparison of optogenetics and chemogenetics in neuromodulation
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