제련소 주변지역 주민들의 PAHs 및 VOCs 노출과 염증 수준 및 만성 질환 간의 관계에 대한 단면 연구

• 영문명: PAHs and VOCs Exposures of Residents Living near a Smelter and Their Relationship to Inflammation and Chronic Diseases: A Cross-Sectional Study
• 발행기관: 한국환경보건학회
• 저자명: 김하늘(Haneul Kim) 조용민(Yong Min Cho) 한다희(Dahee Han) 김미정(Mi Jeong Kim) 채민주(Minju Chae) 조연서(Yeonseo Cho) 이장희(Jang-Hee Lee) 양민호(Min-Ho Yang) 최경화(Kyung-Hwa Choi) 홍영습(Young-Seoub Hong) 김우진(Woo Jin Kim)
• 간행물 정보: 『한국환경보건학회지』제51권 제4호, 222~229쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2025.08.30

국문 초록

Background: Smelters may emit not only metals into their surrounding areas, but polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) as well. These environmental pollutants induce inflammatory responses and may increase the risk of chronic disease history. Objectives: This cross-sectional study investigated the association among exposure to organic pollutants, levels of high-sensitivity C-reactive protein (hs-CRP), and chronic disease history in residents who have lived in the vicinity of a smelter. Methods: Urine samples were collected from 110 residents near a smelter. A survey of residents included questions on their general characteristics and chronic disease history. Four urinary metabolites of PAHs were analyzed using gas chromatography-mass spectrometry, and four metabolites of VOCs were analyzed using liquid chromatography-mass spectrometry. The levels of hs-CRP were analyzed using an automated chemistry analyzer. General linear regression and logistic regression analyses adjusted for age, sex, income, occupational exposure, smoking, and alcohol consumption were performed. Results: Urinary concentrations of trans, trans-muconic acid and methylhippuric acid significantly increased hs-CRP levels (β=0.286, p-value=0.047; β=0.132, p-value=0.031, respectively). In logistic regression, the risk of cardiovascular disease (CVD) was elevated considerably with hs-CRP (odds ratio=1.908, 95% confidence interval: 1.040, 3.501). Conclusions: This study suggests that VOC exposure may increase the inflammation levels of residents in a smelter area. Furthermore, inflammatory marker levels were positively associated with the risk of CVD.

목차

Ⅰ. 서 론

Ⅱ. 재료 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

감사의 글

Conflict of Interest

References

키워드

Smelter polycyclic aromatic hydrocarbons volatile organic compounds inflammation