AMPK 활성화와 3T3-L1 세포에서 지방 생성 억제를 통한 Lactococcus lactis JNU534 (LLJ)의 항비만 효과

• 영문명: Anti-Obesity Effects of Lactococcus lactis JNU534 via AMPK Activation and Inhibition of Lipogenesis in 3T3-L1 Adipocytes
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 이세경(Sekyung Lee) 이현순(Hyun-Sun Lee) 고주영(Juyoung Koh) 조성민(Sungmin Cho) 정승식(Seungsik Chung) 이효원(Hyowon Lee) 박성선(Sung Sun Park)
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』11권 1호, 30~39쪽, 전체 10쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Obesity is a growing global health issue closely associated with metabolic disorders, and recent studies suggest that probiotics derived from fermented foods may offer promising anti-obesity effects. In this study, we investigated the anti-obesity potential of Lactococcus lactis JNU534 (LLJ), a lactic acid bacterium isolated from kimchi, by examining its effects on adipocyte differentiation and lipid metabolism in 3T3-L1 preadipocytes. LLJ treatment during the differentiation process resulted in a significant reduction in lipid accumulation, accompanied by suppressed expression of key adipogenic transcription factors including C/EBPβ, C/EBPα, PPARγ, and FABP4. Concurrently, LLJ downregulated essential lipogenic genes (SREBP1c, FAS, and HMGCR) and suppressed the expression of NADPH-producing enzymes critical for lipid biosynthesis. Furthermore, LLJ enhanced the phosphorylation of key metabolic regulators (AMPK, ACC, and HSL), thereby activating lipid catabolism while simultaneously inhibiting lipid synthesis. These findings demonstrate that LLJ inhibits adipogenesis and modulates lipid metabolism through AMPK-mediated signaling pathways. As a functional probiotic derived from traditional fermented food, LLJ shows therapeutic potential for obesity prevention and management. However, further in vivo and clinical investigations are warranted to validate its efficacy and identify the specific bioactive compounds responsible for its metabolic benefits.

목차

서 론

재료 및 방법

결 과

고 찰

요 약

References

키워드

Lactococcus lactis JNU534 AMPK signaling pathway anti-obesity lipid metabolism