Baicalin mitigates the reduction of γ-enolase expression caused by middle cerebral artery occlusion in adult rats

• 발행기관: 한국예방수의학회
• 저자명: Hyun-Kyoung Son Phil-Ok Koh
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.49, No.2, 58~64쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Baicalin is known to exhibit neuroprotective effects during brain injury through its antioxidant and anti-inflammatoryfunctions. Moreover, γ-enolase is specifically expressed in nerve cells and exhibits neuroprotective properties. In this study,we investigated whether baicalin regulates γ-enolase expression in an moddle cerebral artery occulsion (MCAO)-induced braininjury model. Adult male rats were intraperitoneally injected with baicalin (100 mg/kg) or phosphate-buffered saline (PBS)immediately after right MCAO surgery. Neurological behavior tests were performed 24 hours after surgery and brain watercontent was evaluated. Right cortical tissue was collected. Western blot analysis were conducted to elucidate γ-enolaseexpression in MCAO animals treated with baicalin. In addition, γ-enolase expression was analyzed using immunofluorescencestaining. MCAO animals administered PBS displayed severe behavioral impairments and edema, whereas baicalin administrationalleviated these disorders, demonstrating the protective effects of baicalin against ischemic damage. Western blot analysisresults showed that MCAO-induced damage decreased γ-enolase expression, and baicalin treatment mitigated this reduction.These findings were confirmed through immunofluorescence staining. Since γ-enolase is known to contribute to neuroprotectiveeffects, these results suggest that baicalin alleviates neurobehavioral impairments in stroke animals and exerts neuroprotectiveeffects by attenuating the decline in γ-enolase expression caused by brain injury. In conclusion, we demonstrated that baicalinregulates γ-enolase expression during cerebral ischemic damage.

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baicalin cerebral ischemia neuroprotection stroke