Role of Biological Sex in the Onset of Muscle Atrophy

• 발행기관: 아시아운동학회
• 저자명: Nicholas P Greene
• 간행물 정보: 『Physical Activity 』Vol.2 No.2, 16~21쪽, 전체 6쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2024.11.30

국문 초록

Skeletal muscle atrophy is comorbid to a number of pathologies and other conditions including cancer, disuse and aging. Atrophy is associated with reduced quality of life and increased mortality, yet effective therapeutic approaches are lacking. Mechanisms of atrophy are known to be highly heterogeneous across stimuli with the primary conserved similarity being the development of a negative protein balance (protein degradation exceeding protein synthesis). In recent years divergence of atrophic mechanisms between biological sexes is starting to become better recognized. This sexual dimorphism is currently poorly understood but also critical to development of efficacious therapies to prevent, attenuate or reverse atrophy. The purpose of this mini-review is to explore the heterogeneity of the onset of muscle atrophy with specific consideration of biological sex. This is not intended to be a fully encompassing consideration but rather a primer to heterogeneity of muscle atrophy across biological sexes in the onset of atrophy.

키워드

Cancer cachexia Disuse Denervation Protein balance Mitochondrial degeneration

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