Mechanobiology and Mitochondria in Muscle Angiogenesis and Blood-Brain Barrier Dysfunction

• 영문명: Mechanobiology and Mitochondria in Muscle Angiogenesis and Blood-Brain Barrier Dysfunction
• 발행기관: 아시아운동학회
• 저자명: Joon-Young Park Chatnapa Panusatid
• 간행물 정보: 『Physical Activity 』Vol.2 No.2, 11~15쪽, 전체 5쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2024.11.30

국문 초록

Mechanobiology, the study of mechanical forces influencing cellular behavior, plays a critical role in vascular health and disease, particularly in endothelial cells. This mini-review explores the intersection of mechanobiology and mitochondrial remodeling in endothelial cells, with a focus on their implications for muscle angiogenesis and blood-brain barrier (BBB) dysfunction. Endothelial cells are subjected to varying hemodynamic forces, such as unidirectional laminar and disturbed flow, which activate distinct mechanotransduction pathways and result in different cellular phenotypes. These forces regulate mitochondrial function, including bioenergetic adaptations and biosynthetic processes, which are crucial for endothelial cell responses in vascular remodeling, angiogenesis, and BBB integrity. Exercise-induced shear stress provides a context for understanding how these mechanical forces influence mitochondrial biogenesis, dynamics (e.g., fusion/fission), and mitophagy in endothelial cells. Notably, unidirectional flow enhances mitochondrial function and endothelial cell quiescence, while disturbed flow promotes glycolysis and endothelial activation, contributing to pathologies such as atherosclerosis. This review emphasizes the need for further research into the molecular mechanisms linking mechanotransduction and mitochondrial function, particularly their roles in endothelial cell metabolism and vascular adaptation.

키워드

Exercise Wall shear stress Mitochondria Angiogenesis

참고문헌

• Antioxid Redox Signal
• Physiol Rev
• JAMA
• Am J Physiol Heart Circ Physiol
• Am J Physiol Heart Circ Physiol
• Am J Physiol Heart Circ Physiol
• Ann Biomed Eng
• J Vasc Surg
• Free Radic Biol Med
• Nature
• Proc Natl Acad Sci U S A
• PLoS One
• Proc Natl Acad Sci U S A
• Biochim Biophys Acta
• Proc Natl Acad Sci U S A
• J Cell Physiol
• Antioxid Redox Signal
• Cell Death Dis
• Atherosclerosis
• Redox Biol
• Am J Physiol Regul Integr Comp Physiol
• Arterioscler Thromb Vasc Biol
• Am J Physiol Cell Physiol
• Elife