염증성 장질환과 뇌질환의 상호작용: 장-뇌 축의 최신 이해

• 영문명: Interactions between Inflammatory Bowel Disease and Brain Disorders: A Current Understanding of the Gut-Brain Axis
• 발행기관: 대한약학회
• 저자명: 도영주(Youngju Do) 박대현(Daehyun Park) 임은옥(Eunok Im)
• 간행물 정보: 『약학회지』제68권 제6호(2024년), 429~437쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Inflammatory bowel disease (IBD), which primarily includes Crohn’s disease and ulcerative colitis, is characterized by chronic gastrointestinal inflammation and has a rising incidence globally. This review examines the link between IBD and neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and depression, focusing on shared inflammatory mechanisms through the gut-brain axis. Intestinal inflammation affects neurodegenerative conditions by acting through the vagus nerve and blood vessels. Genetic overlaps, including mutations in BIN1, TNF, LRRK2, and NOD2, have been identified in IBD, Alzheimer’s disease, and Parkinson’s disease, suggesting common pathways in disease progression. Additionally, IBD is associated with a higher risk of neuropsychiatric disorders, indicating that gut inflammation may contribute to changes in brain structure and function. Although the precise mechanisms remain unclear, ongoing research into the gut-brain axis is expected to enhance our understanding of its impact on brain health and pave the way for new therapeutic interventions. This review synthesizes current knowledge on the interplay between IBD and brain disorders, offering valuable insights for future research and clinical applications.

목차

서 론(Introduction)

알츠하이머병(Alzheimer’s Disease)

파킨슨병(Parkinson’s Disease)

우울증 및 정신질환(Depression and Mental Diseases)

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Inflammatory Bowel Disease Gut-Brain Axis Alzheimer’s Disease Parkinson’s Disease Neuroinflammation