바이오마커 기반 알츠하이머병 최신 진단기술: 조기 진단법 개발을 위한 연구개발 현황을 중심으로

• 영문명: Current Methodologies of Biomarker-Based Alzheimer’s Diagnosis: Paving the Path for Early Detection of Disease
• 발행기관: 대한약학회
• 저자명: 장민선(Minsun Chang)
• 간행물 정보: 『약학회지』제68권 제6호(2024년), 409~428쪽, 전체 20쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Alzheimer’s disease (AD) is a degenerative neurological disorder characterized by progressive cognitive decline and memory impairment, accounting for approximately 70% of dementia cases. AD is irreversible, and once it manifests, it continuously worsens. With the aging population, the prevalence of AD is increasing, underscoring the necessity of early diagnosis. Early diagnosis is crucial for slowing the progression of AD and enhancing the potential for effective treatment. This study reviews the current research and development status of biomarker-based diagnostic methods for AD, emphasizing the latest diagnostic technologies. Biomarkers play a critical role in drug development and treatment efficacy monitoring, and early diagnostic technologies are essential for proactively addressing neurodegenerative diseases like AD. Currently, the most widely used the most widely used AD diagnostic technologies include amyloid and tau biomarker diagnostics via PET imaging and cerebrospinal fluid analysis. Additionally, genetic testing and blood-based biomarker diagnostics are actively being explored. This review examines various biomarker discovery and measurement methods from molecular and clinical perspectives and discusses trends in the development of new diagnostic devices and technologies.

목차

서 론(Introduction)

알츠하이머병(AD) 진단과 바이오마커 기반 진단방법 현황

바이오마커 기반 알츠하이머병(AD) 진단기술 연구개발 동향

결 론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Alzheimer’s disease Biomarkers Diagnosis Amyloid beta Tau Neurodegeneration