치아우식을 유발하는 Streptococcus mutans에 대한 억제효과를 가진 김치 유래 유산균 Latilactobacillus sakei subsp. sakei THYJ-15

• 영문명: Anticariogenic Effects of Latilactobacillus sakei subsp. sakei THYJ-15 Isolated from Kimchi against Streptococcus mutans
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 정제용 유두나 권예지 이은지 Nguyen Thi Minh Trang 국무창 이태후
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』9권 1호, 31~38쪽, 전체 8쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

Dental caries is an infectious disease that is caused by the interaction between the host, the diet, and a diverse microbial community. This study illustrated the anticariogenic effects of THYJ-15 against Streptococcus mutans, a major agent of dental caries. THYJ-15 was identified as Latilactobacillus sakei subsp. sakei through 16S rRNA sequencing, with a similarity of 99.72% to L. sakei subsp. sakei JCM 1157T. The cell-free supernatant of L. sakei subsp. sakei THYJ-15 observed MIC values of 10 mg/mL and MBC values of 20 mg/mL against S. mutans KACC 16833T. The cell-free supernatant of L. sakei subsp. sakei THYJ-15 showed significant inhibitory effects on biofilm formation, acid production and glucosyltransferases(GTFs) production against S. mutans. As a results, it was confirmed that L. sakei subsp. sakei THYJ-15 is a lactic acid bacterium possessing notable anticariogenic effects. Accordingly, L. sakei subsp. sakei THYJ-15 is expected to have great potential to be used as a basic substance for dental caries treatment caused by S. mutans.

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키워드

Latilactobacillus sakei subsp. sakei THYJ-15 anticariogenic antibiofilm Kimchi Streptococcus mutans