Antiproliferative Activity of Allium monanthum in HT-29 Human Colorectal Adenocarcinoma Cells

• 영문명: Antiproliferative Activity of Allium monanthum in HT-29 Human Colorectal Adenocarcinoma Cells
• 발행기관: 한국차학회
• 저자명: Ha Sook Chung
• 간행물 정보: 『한국차학회지』제28권 제3호, 22~32쪽, 전체 11쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2022.09.30

영문 초록

This study was designed to identify the phytochemicals of Allium monanthum with antiproliferative effect on HT-29 human colorectal adenocarcinoma cells through the activity-guided fractionation and isolation method. In particular, compounds 1-8 were isolated from A. monanthum, and determined to be apigenin (1), isorhamnetin (2), 5,7,3′,4′-tetrahydroxy-3-methoxyflavone (3), luteolin (4), myricetin (5), isorhamnetin-3-O-β-D-glucoside (6), isorhamnetin-3-O-β-D-rutinoside (7), and luteolin-7-O-β-D-glucoside (8) by comparing the 1D-, 2D-NMR, and ESI-MS spectral data. Of these, compound 5 significantly decreased the cell viability (IC50, 48.21 ± 1.07 μM) with a morphological change, indicative of apoptosis, resulting in activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner.

키워드

Allium monanthum flavonoids myricetin HT-29 cells alternative tea