어성초에서 동정한 화합물의 항산화 및 아세틸콜린에스테라아제 저해 활성

• 영문명: Anti-acetylcholinesterase and Antioxidant Effects of Identified Compounds from Houttuynia cordata
• 발행기관: 한국차학회
• 저자명: 현숙경(Sook Kyung Hyun)
• 간행물 정보: 『한국차학회지』제28권 제3호, 16~21쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2022.09.30

영문 초록

Houttuynia cordata Thunb. (Saururaceae), a widely used herbal medicine and popularly consumed as a healthy vegetable, exhibits anti-inflammatory, antioxidant, and antitumor activities. In particular, H. cordata contains a lot of alkaloids and flavonoids, such as quercitrin and quercetin. So, research on the preparation of food and functional cosmetics, such as the ones used for anti-aging and hair loss prevention, using H. cordata is in progress. Therefore, this study identified the active compounds of H. cordata using HPCL and evaluated the acetylcholinesterase (AChE) inhibitory and antioxidant activities of these compounds. In particular, cryptochlorogenic acid, which is a phenolic compound, and apigenin, afzelin, quercitrin, and hyperoside, which are flavonoids, were detected in H. cordata. Among them, quercitrin was the major content of H. cordata at 1.326 mg/g, followed by the hyperoside, afzelin, and cryptochlorogenic acid contents of 0.678, 0.157, and 0.140 mg/g, respectively. Likewise, only apigenin did not show any antioxidant activity, but other active compounds showed very good scavenging activity. Finally, apigenin, afzelin, cryptochlorogenic acid, quercitrin, and hyperoside had an AChE inhibitory activity of 98.49, 79.77, 64.13, 61.97, and 27.4 % in 100 μg/mL, respectively. So, in the future, the results of this study will be used to develop and commercialize functional tea products.

키워드

Houttuynia cordata antioxidant acetylcholinesterase flavonoid phenolic compound