한국인 모유영양아로부터 분리한 Enterococcus faecium ID9201의 콜레스테롤 저하효과

• 영문명: Cholesterol Lowering Effect of Enterococcus faecium ID9201 Isolated from Breast Milk-Fed Korean Infant
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 이승훈(Seung-Hun Lee) 김영후(Young-Hoo Kim) 김민구(Min-Goo Kim) 강재훈(Jae-Hoon Kang) 강대중(Dae-Jung Kang)
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』Current Topics in Lactic Acid Bacteria and Probiotics 3권 2호, 41~45쪽, 전체 5쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2015.12.30

영문 초록

We selected lactic acid bacteria to reduce cholesterol levels in vitro and in vivo. Among the 140 strains tested, a strain ID9201 was shown to reduce cholesterol in the spent medium over 30% and to increase cholesterol in cell pellet. A strain ID9201 isolated from breast milk-fed Korean infant feces was identified as Enterococcus faecium on the basis of morphological analysis, biochemical analysis (API kit), and 16S rDNA sequence analysis. A freeze-dried powder of the strain was fed to Sprague-Dawley(SD) rats with high cholesterol diet for 6 wk. In the control group fed cholesterol enriched diet without probiotics, the serum cholesterol increased by 1.9 times in comparison with the initial value. Among the test group, ID9201 group showed the lowest cholesterol increase, 1.5 times of initial serum cholesterol, as in the blank group fed normal diet without probiotics. Based on these data, we assumed that ID9201 inhibited intestinal absorption of dietary cholesterol.

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키워드

Enterococcus faecium ID9201 cholesterol conjugated bile acid deconjugated bile acid bile salt hydrolase