정신병적 증상을 동반한 알츠하이머병에서 앞쪽뇌량 부피의 감소

• 영문명: Reduced Volume of Anterior Corpus Callosum in Alzheimer’s Disease With Psychotic Symptoms: Cross-Sectional Magnetic Resonance Imaging Study
• 발행기관: 대한노인정신의학회
• 저자명: 이현지(Hyunji Lee) 이영민(Young-Min Lee) 박제민(Je-Min Park) 이병대(Byung-Dae Lee) 문은수(Eunsoo Moon) 정희정(Hee-Jeong Jeong) 서화규(Hwagyu Suh) 김경원(Kyungwon Kim) 김학진(Hak-Jin Kim) 박경준(Kyongjune Park) 최경운(Kyung-Un Choi)
• 간행물 정보: 『노인정신의학』노인정신의학 제26권 제1호, 12~17쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Objective: Although previous studies have shown association between anterior corpus callosum (ACC) and various psychotic disorder, the effect of ACC on development on psychotic symptoms in Alzheimer’s disease (AD) is still unclear. The purpose of this study is to investigate the association of ACC with the development of psychosis in patients with AD. Methods: This is a hospital based cross-sectional study of 241 AD patients. The main outcome measure is the volume of ACC that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance and Logistic regression analysis conducted to assess the association between the volume of ACC and the presence of psychosis in AD, adjusting for age, education, Clinical Dementia Rating-Sum of Boxes, and total intracranial volume. Results: We found that the volume of ACC is significantly reduced in AD with psychosis (AD+P) compared to AD without psychosis (AD-P) (774.27±142.96 vs. 833.09±142.04, p=0.005). The volume of ACC associated with the presence of psychosis in AD (odds ratio=0.995; 95% confidence interval=0.993-0.997; p=0.006). Conclusion: We have found that reduced volume of ACC in AD+P, suggesting that ACC might play an important role in the underlying pathogenesis of development of psychotic symptoms in AD.

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키워드

Anterior corpus callosum Psychosis Alzheimer’s disease