금화규(Abelmoschus manihot) 뿌리 추출물의 면역증진 및 항비만효과

• 영문명: Immuno-enhancing and Anti-obesity Effect of Abelmoschus manihot Root Extracts
• 발행기관: 한국자원식물학회
• 저자명: 유주형(Ju Hyeong Yu) 금나경(Na Gyeong Geum) 여주호(Joo Ho Ye) 정진부(Jin Boo Jeong)
• 간행물 정보: 『한국자원식물학회지』제34권 제5호, 411~419쪽, 전체 9쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

In this study, we investigated in vitro immune-enhancing and anti-obesity activity of Abelmoschus manihot roots (AMR) in mouse macrophage RAW264.7 cells and mouse adipocytes 3T3-L1 cells. AMR increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in RAW264.7 cells. The inhibition of toll like receptor (TLR) 2 and 4 blocked AMR-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of mitogen-activated protein kinases (MAPKs) signaling pathway reduced AMR-mediated production of immunostimulatory factors. From these results, AMR is considered to have immune-enhancing activity through TLR2/4-mediated activation of MAPKs signaling pathway. In addition, AMR inhibited lipid accumulation and reduced the protein level such as CCAAT enhancer-binding protein alpha (CEBPα), peroxisome proliferator-activated receptor gamma (PPARγ), perilipin-1, adiponectin and fatty acid binding protein 4 (FABP4) associated with lipid accumulation in 3T3-L1 cells, indicating that AMR may have anti-obesity activity. Based on these results, AMR is expected to be used as a potential functional agent for immune enhancement and anti-obesity.

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서 언

재료 및 방법

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키워드

Adipocytes Abelmoschus manihot Anti-obesity activity Immune-enhancement Macrophage