Safety and efficacy of 10-fraction hypofractionated radiation therapy for non-small cell lung cancer

• 발행기관: 대한방사선종양학회
• 저자명: Ye Jin Yoo Su Ssan Kim Si Yeol Song Jong Hoon Kim Seung Do Ahn Sang-wook Lee Sang Min Yoon Young Seok Kim Jin-hong Park Jinhong Jung Eun Kyung Choi
• 간행물 정보: 『대한방사선종양학회지』제39권 제3호, 202~209쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2021.09.30

영문 초록

Purpose: To investigate the safety and efficacy of hypofractionated radiation therapy (HFRT) in patients with non-small cell lung cancer who are unfit for surgery or stereotactic body radiation therapy (SBRT) at our institution. Materials and Methods: From May 2007 to December 2018, HFRT was used to treat 68 lesions in 64 patients who were unsuitable for SBRT because of central tumor location, large tumor size, or contiguity with the chest wall. The HFRT schedule included a dose of 50–70 Gy delivered in 10 fractions over 2 weeks. The primary outcome was freedom from local progression (FFLP), and the secondary endpoints included overall survival (OS), disease-free survival, and toxicities. Results: The median follow-up period was 25.5 months (range, 5.3 to 119.9 months). The FFLP rates were 79.8% and 67.8% at 1 and 2 years, respectively. The OS rates were 82.8% and 64.1% at 1 and 2 years, respectively. A larger planning target volume was associated with lower FFLP (p = 0.023). Dose escalation was not associated with FFLP (p = 0.964). Four patients (6.3%) experienced grade 3–5 pulmonary toxicities. Tumor location, central or peripheral, was not associated with either grade 3 or higher toxicity. Conclusion: HFRT with 50–70 Gy in 10 fractions demonstrated acceptable toxicity; however, the local control rate can be improved compared with the results of SBRT. More studies are required in patients who are unfit for SBRT to investigate the optimal fractionation scheme.

목차

Introduction

Materials and Methods

Results

Discussion and Conclusion

Conflict of Interest

References

키워드

Non-small cell lung carcinomas Radiation dose fractionation Radiation dose hypofractionation Treatment outcome Toxicity