랫드에 미치는 Permethrin의 발생독성에 관한 연구

• 영문명: Effect of Permethrin on Embryonic Developments in Rats
• 발행기관: 한국환경보건학회
• 저자명: 윤효정(Hyojung Yoon) 정문호(Moonho Chung)
• 간행물 정보: 『한국환경보건학회지』제31권 제4호, 254~259쪽, 전체 6쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2005.08.30

영문 초록

Permethrin, a synthetic pyrethroid insecticide, has been widely used to protect domestic animals and the public health, as well as in agriculture against a variety of pests, which provides potential for environmental exposure. Permethrin is classified as possible human carcinogen and endocrine disrupting chemical by many international authorities. However, its developmental effects have been rarely studied. This study investigated the effects of permethrin during embryogenesis. Developmental toxicity of permethrin was evaluated using short-term in vitro battery system. Gestation day 9.5 rat embryos (organogenesis) were cultured with permethrin (0.1, 0.4 and 0.8 mg/ml) for 48 hours using whole embryo culture system. All the treatments exhibited significant decreases in the total morphological score. Permethrin induced significant growth retardation and the developmental abnormality at doses of 0.4 and 0.8 mg/ml. Moreover, the DNA and protein contents of embryos decreased in dose-dependent manner. These observations suggest that permethrin contributes to toxicity on embryonic developments in rats.

목차

Ⅰ. 서론

Ⅱ. 재료 및 연구 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결론

키워드

permethrin rat organogenesis developmental toxicity whole embryo culture