한국 남성에서 혈청 총빌리루빈 농도와 동맥경직도의 관련성

• 영문명: Association between Serum Total Bilirubin Levels and Arterial Stiffness in Korean Men
• 발행기관: 대한임상노인학회
• 저자명: 윤은경(Eunkyeong Yun) 이용제(Yong-Jae Lee)
• 간행물 정보: 『대한임상노인학회지』대한임상노인의학회지 제21권 제1호, 26~31쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.06.30

영문 초록

Background: We aimed to investigate the relationship between serum total bilirubin levels and arterial stiffness assessed based on brachial-ankle pulse wave velocity (PWV) in Korean men aged 45 years and older.Methods: This cross-sectional study included a total of 1387 individuals who underwent health check-ups between November 2006 and July 2010 at the Health Promotion Center of Gangnam Severance Hospital. Their serum total bilirubin levels were categorized into quartiles: Q1, 0.3-0.7; Q2, 0.8-0.9; Q3, 1.0-1.1; and Q4, 1.2-2.8 mg/dL. A high PWV was defined as more than the 75th percentile of the participants (≥1530 cm/s). The odds ratios (ORs) and 95% confidence intervals (CIs) for high PWVs were calculated using multiple logistic regression analysis after adjusting for confounding factors across the serum total bilirubin quartiles. Results: Compared with that of the highest quartile, the OR of the lowest quartile was 1.56 (95% CI: 1.04-2.41) for total bilirubin levels after adjusting for age, body mass index, smoking status, alcohol consumption, exercise frequency, blood pressure, fasting plasma glucose levels, triglyceride levels, and high-density lipoprotein levels.Conclusion: Serum total bilirubin levels are inversely associated with arterial stiffness in Korean men.

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ORCID

REFERENCES

키워드

Arterial stiffness Bilirubin Pulse wave velocity