녹차 열수 추출물의 인체 대장암세포 증식억제 효과

• 영문명: Effects of Hot Water Extracts of Camellia sinensis L. on Human Colon Cancer Cell Line
• 발행기관: 한국차학회
• 저자명: 김민지(Min Ji Kim) 정하숙(Ha Sook Chung)
• 간행물 정보: 『한국차학회지』제17권 제4호, 100~105쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

The anticancer activity of Camellia sinensis L. on human colon cancer cell line, was investigated for the identification of functionality of organic tea. Camellia sinensis L. was extracted with hot water for 3 hr, three times to give hot water extracts. The anti-proliferative activity of hot water extracts in human colon cancer cell line(HT-29) was identified through cancer cell viability, cell cycle and RT-PCR analyses. In our study, the growth of colon cancer cell was inhibited with hot water extracts of C. sinensis L. in a dose-dependent manner. It was also stimulated apoptosis by Annexin V FITC and PI experiments. The expression of Bcl-2 was decreased treated with hot water extracts of C. sinensis L., whereas, p53 was increased. These results suggest the hot water extracts of C. sinensis L. might inhibit the growth of human colon cancer cells by various apoptosis-aiding activities as well as apoptosis itself.

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Camellia sinensis L. organic hot water extracts human colon cancer cell line apoptosis