A short review of arsenic-induced toxicity

• 발행기관: 한국예방수의학회
• 저자명: Soohee Kim Doug-Young Ryu
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.40, No.1, 46~52쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.03.30

영문 초록

Arsenic is an environmental pollutant and is known to induce toxicity. Arsenic acts on cells through a variety of mechanisms, influencing numerous signal transduction pathways. It induces a variety of cellular effects such as apoptosis, growth inhibition, promotion or inhibition of differentiation and angiogenesis. Arsenic has been associated with cancers of the skin, bladder, lung, kidney, and liver as well as with noncancerous conditions, diabetes and hepatopathy. However, arsenic trioxide (ATO) was reported to induce remission in patients with acute promyelocytic leukemia (APL). The anticancer efficiency of ATO was not restricted to APL; however, it has been extended to many solid tumors, including liver, cervical, prostate, lung, esophagus, and bladder tumors. Therefore, in this study, a number of previous studies are summarized that demonstrate arsenic-induced toxicity, including carcinogenesis and anticancer activity in vitro and in vivo. The arsenic metabolism that is involved in arsenic-induced toxicity is also discussed.

목차

INTRODUCTION

ARSENIC METABOLISM

ARSENIC-INDUCED TOXICITY

CARCINOGENESIS

ANTICANCER ACTIVITY

CONCLUSION

키워드

Arsenic carcinogenesis anticancer activity in vivo study