밀싹 추출물의 ERK와 Akt 인산화를 경유한 인간 모유두세포 증식 촉진효과

• 영문명: Wheat Sprout Extract Stimulates Cell Proliferation via Phosphorylation of ERK and Akt in Human Dermal Papilla Cells
• 발행기관: 대한약학회
• 저자명: 박설아(Seol a Park) 인명희(Myoung hee In) 우원홍(Won hong Woo) 문연자(Yeun ja Mun)
• 간행물 정보: 『약학회지』제61권 제3호(2017년), 158~163쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.06.30

영문 초록

We investigated the effect of Wheat Sprout MeOH extract (WSM) on cell proliferation, and analyzed the molecular mechanism in human hair dermal papilla cells (HHDPCs). After exposure to WSM in HHDPCs, cell proliferation was increased compared with minoxidil-treated cells. Treatment with WSM led to phosphorylation of extracellular signal-related kinase (ERK) and Akt. Moreover, WSM-mediated increase of cell proliferation was attenuated by PD98059, ERK inhibitor, and LY294002, Akt inhibitor. These results suggest that WSM induced cell proliferation in HHDPCs through activation of ERK and Akt.

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실험재료 및 방법

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결 론

감사의 말씀

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키워드

Wheat Sprout HHDPCs Cell Proliferation ERK Akt