Licochalcone E 유도체들이 LPS에 의해 유도된 염증조절 분자들의 생성에 미치는 영향

• 영문명: Effects of Licochalcone E Derivatives on the Production of Inflammatory Mediators Induced by LPS
• 발행기관: 대한약학회
• 저자명: 조영창(Young Chang Cho) 윤구(Goo Yoon) 천승훈(Seung Hoon Cheon) 강복윤(Bok Yun Kang)
• 간행물 정보: 『약학회지』제61권 제3호(2017년), 171~177쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.06.30

영문 초록

Licochalcone E is a retrochalcone isolated from the roots of Glycyrrhiza inflate. We previously reported that licochalcone E inhibited IL-12p40 production and attenuated chronic allergic contact dermatitis (ACD). Among the derivatives of licochalcone E, compound #74 ((E)-3-(5-Bromo-4-hydroxy-2-methoxyphenyl)-1-(4-ethoxyphenyl)prop-2-en-1-one) inhibited the production of IL-12p40, TNF-α, and IL-6, and NF-κB signaling pathway from LPS stimulated RAW264.7 macrophages. The effect of compound #74 (0.5, 1, and 5%) on ACD model was very weak.

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키워드

Licochalcone E derivatives Macrophage Inflammation Cytokines