천연고분자 기재에 의한 수용성 항고지단백혈증제의 흰쥐 피부투과 특성

• 영문명: Skin Permeation Characteristics of Antihyperlipoproteinemic Agent using Natural Polymer Bases in Rats
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 공승대(Seung Dae Kong) 황성규(Sung Kwy Hwang) 정덕채(Duck Chae Jung)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제17권 제2호, 126~131쪽, 전체 6쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2000.06.30

영문 초록

Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as oxiniacic acid in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.

목차

Abstract

Ⅰ. 서론

Ⅱ. 실험 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결론

참고문헌