진행성 하인두암에서 선행화학요법과 방사선요법

• 영문명: Neoadjuvant Chemotherapy and Radiotherapy for the Treatment of Advanced Hypopharyngeal Carcinoma
• 발행기관: 대한두경부종양학회
• 저자명: 이효정(Hyo Jeong Lee) 성명훈(Myung Whun Sung) 박범정(Bum Jung Park) 이명철(Myung Chul Lee) 심우섭(Woo Sub Sim) 성원진(
• 간행물 정보: 『대한두경부종양학회지』제18권 제1호, 41~45쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2002.05.30

영문 초록

Background and Objectives: To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. Materials and Methods: Medical records and radiologic findings of 107 patients with squamous cell carcinoma of the hypopharynx, Stage III or IV (AJCC, 1997), were retrospectively reviewed. Results: Neoadjuvant chemotherapy followed by radiation therapy showed 74% complete remission (CR) rate. The patients who did not show CR after chemotherapy had a high likelihood of treatment failure, even though they achieved CR following subsequent radiotherapy. Twenty-eight of 57 patients were able to preserve their larynges for more than three years by chemotherapy and radiation. Conclusions: This approach appeared to be as effective as radical surgery with postoperative radiation therapy without comprising of survival. To improve the cure rates, we need to develop better strategies to increase CR rates with chemotherapy and determine the best treatment option for patients who are partially or nonresponsive to chemotherapy.

목차

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키워드

하인두암 선행화학요법 방사선요법 Hypopharyngeal carcinoma Neoadjuvant chemotherapy Radiotherapy