비인강암에서 동시 항암방사선치료와 방사선치료 단독의 비교 연구

• 영문명: Concurrent Chemoradiotherapy versus Radiation Alone in Nasopharyngeal Carcinoma
• 발행기관: 대한두경부종양학회
• 저자명: 박진홍(Jin hong Park) 장혜숙(Hye sook Chang) 김성배(Sung Bae Kim) 김상윤(Sang Yoon Kim) 남순열(Soon Yuhl Nam) 조경자(K
• 간행물 정보: 『대한두경부종양학회지』제18권 제1호, 30~35쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2002.05.30

영문 초록

Objective: To determine the effectiveness and toxicity of chemoradiation therapy in nasopharyngeal carcinoma by comparing with radiation therapy alone. Materials and Methods: Between October 1989 and July 2000, One hundred eleven patients with newly diagnosed and histologically proven nasopharyngeal carcinoma treated in Department of Radiation Oncology, Asan Medical Center were retrospectively reviewed. Forty-five patients were treated with radiation therapy alone (Group I) and 66 patients were treated with radiation therapy and concurrent cisplatin (Group II). Cisplatin was administered once a week, on the first day of each successive week of treatment, starting on day 1 of radiation therapy and given as a intravenous bolus at a dose of 20mg/m 2 of body-surface area. Radiation therapy was given in doses of 1.8Gy, once a day, 5 days per week with 4MV or 6 MV photons. Initial field was received a total of 60Gy and a primary tumor and enlarged lymph nodes were boosted with an high dose intracavitory brachytherapy and 3D conformal therapy. Results: The complete response rate was 86.7% in Group I, and was 90.9% in Group II. The 5 year overall survival rate for Group I was 60% and for Group II was 45% (p=0.2520). The 5 year disease free survival rate was 52% versus 45%, respectively (p=0.7507). The median follow up was 44 months versus 34 months, respectively. Conclusion: Analysis of the III patients showed no significant difference in disease free survival and overall survival in two treatment group. This retrospective analysis did not demonstrate benefit with concurrent chemoradiation using cisplatin at a dose of 20mg/m 2 of body-surface area in treatment result than radiation alone.

목차

Abstract

서론

대상 및 방법

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고찰

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키워드

비인강암 방사선 치료 항암화학요법 Nasopharyngeal carcinoma Radiation therapy Chemotherapy