두경부 편평상피세포암과 절제연에서 Human Telomerase Reverse Transcriptase의 발현

• 영문명: Immunohistochemistry of Human Telomerase Reverse Transcriptase in Head and Neck Squamous Cell Carcinoma and Resection Margin
• 발행기관: 대한두경부종양학회
• 저자명: 김용범(Yong Bum Kim) 노경섭(Kyung Sup Rho) 홍남표(Nam Pyo Hong) 안회영(Hwoe Young Ahn) 이용식(Yong Sik Lee) 송영호(You
• 간행물 정보: 『대한두경부종양학회지』제18권 제1호, 18~22쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2002.05.30

영문 초록

Background and Objectives: The expression of telomerase, a ribonucleoprotein complex, has been detected in tissues from many human cancers, but not in the majority of normal tissues except germ cell. It is believed that the activation of telomerase is linked to celluar immortality and may playa role in tumorigenesis. Human telomerase reverse transcriptase (hTERT) has been identified as a putative catalytic subunit of human telomerase and its expression is closely correlated with telomease activity. We studied the expression of hTERT in head and neck squamous cell carcinoma (HNSCC) and resection margin by immunohistochemistry for hTERT and evaluate the correlation between hTERT expression and clinical data in HNSCC. Materials and Methods: We performed a immunohistochemistry in 17 cases of HNSCC and 10 cases of resection margins, histologically normal. The correlations between the hTERT expression and the clinical data in HNSCC were analyzed. Result: hTERT immunoreactivities were detected in 14 of 17 (82.4%) HNSCC, 1 of 10 (10%) resection margin. No correlation was observed between clinical data and hTERT expression in HNSCC. Conclusion: hTERT is activated in HNSCC and its expression is independent from clinical data of patients.

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키워드

면역조직화학염색 편평세포암 Telomerase Immunohistochemistry hTERT Squamous cell carcinoma