갑상선 여포상 선종과 암종의 감별진단에서 p27KIP1, MIB-1, bcl-2, p53 발현의 유용성에 대한 연구

• 영문명: The Significance of p27KIP1, MIB-1, bcl-2 and p53 Expression in the Differential Diagnosis of Follicular Adenoma and Carcinoma of the Thyroid Gland
• 발행기관: 대한두경부종양학회
• 저자명: 강미선(Mi Seon Kang) 윤혜경(Hye Kyoung Yoon) 김상효(Sang Hyo Kim) 윤기영(Ki Young Yoon) 이충한(Choong Han Lee) 최경현(
• 간행물 정보: 『대한두경부종양학회지』제17권 제2호, 139~147쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2001.11.30

영문 초록

Objectives: The most important differential point of follicular carcinoma from adenoma is capsular invasion or angioinvasion of follicular cells. Serial sections for examination of levels of tumor margins are necessary to watch the invasion. However, the interpretation of capsular invasion or angioinvasion is sometimes not feasible on the routine staining of tumor tissue. The aim of this study is to evaluate the clinical significance of expressions of p27KIP1, MIB-1, bcl-2 and p53 in differential diagnosis of follicular adenoma and carcinoma. Materials and Methods: 16 cases of follicular carcinoma and 26 cases of follicular adenoma were entered on study of immunohistochemical stains for p27KIP1, MIB-1, bcl-2 and p53. In carcinoma cases, correlation between the above markers, patient's age, tumor size, infiltration pattern and metastasis was studied. Results: p27KIP1 labelling index (LI) of follicular carcinoma and adenoma was 4.89±6.92 and 14.52±9.17, respectively, but there was no significant difference between adenoma and carcinoma (p=0.2560). MIB-1 LI of carcinoma and adenoma was 4.11±3.89 and 0.80±0.75, respectively, and MIB-1 LI was significantly higher in carcinoma (p=0.0000). bcl-2 expression was seen in 2(12.5%) of 16 carcinoma cases and 130(50.0%) of 26 adenoma cases, and bcl-2 expression rate was higher in adenoma than in carcinoma(p=0.014). In one adenoma and one carcinoma case, p53 expression was noted. In follicular adenoma with atypia compared to adenoma without atypia, lower p27KIP1 LI, higher MIB-1 LI and lower bcl-2 expression rate were seen. In follicular carcinoma, MIB-1 LI was significantly higher in invasive carcinoma(p=0.045) and was relatively increased in tumors larger than 3.0cm, showing angioinvasion and distant metastasis. But p27KIP1 LI was higher in cases over 40 years old(p=0.008) and with conspicuous capsular invasion. There were no positive correlations between expressions of MIB-1, bcl-2 and p53. Conclusion: MIB-1 labelling index and bcl-2 expression could be helpful for differential diagnosis of follicular adenoma and carcinoma, but p53 showed very low expression rate and no significance in differential diagnosis. p27KIP1 labelling index reveals decreasing tendency in carcinoma compared with adenoma, MIB-1 LI was considered as a poor prognostic marker in follicular carcinoma, but p27KIP1 LI was higher in carcinoma cases over 40 years old with showing conspicuous capsular invasion. Further study for the significance of p27KIP1 labelling index in follicular neoplasms is necessary to evaluate diagnostic value of follicular carcinoma.

목차

Abstract

서론

재료 및 방법

연구결과

암종에서 p27KIP1 및 MIB-1 발현과 예후인자와의 연관성

고찰

결론

References

키워드

여포상 선종 여포상 암종 Follicular adenoma follicular carcinoma p27KIP1 MIB-1 bcl-2 p53