두경부 악성 종양 조직내 간질액 압력

• 영문명: Tumor Interstitial Fluid Pressure in Patients with Head and Neck Cancer
• 발행기관: 대한두경부종양학회
• 저자명: 조문준(Moon June Cho) 김재성(Jae Sung Kim) 이인태(ln tae Lee) 김준상(Jun Sang Kim) 장지영(Ji Young Jang) 김기환(Ki Hwan Kim)
• 간행물 정보: 『대한두경부종양학회지』제16권 제1호, 9~13쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2000.05.30

영문 초록

Objectives: To determine the tumor interstitial fluid pressure(TIFP) in patients with head and neck cancerand predict radiotherapy outcome. Materials and Methods: In 12 biopsy proven primary head and neck cancer patients with accessible by direct inspection and palpation, and of sufficient thickness(>1cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy using a modified wick-in-needle technique. Tumor size was measured clinically and radiologically. Results: The mean preradiotherapy TIFP was 23.4mmHg. Preradiotherapy TIFP had significant relationship with tumor size(p=0.0009). Preradiotherapy TIFP was not different between complete response group and partial or less response group(p=0.114). Radiotherapy outcome was not different between group with above and group with below average TIFP(p=0.09). Conclusion: The mean TIFP was elevated with 23.4mmHg before radiation therapy. Preradiotherapy TIFP had significant relationship with tumor size. It is not definitive that TIFP could be prognostic indicator of radiation response.

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키워드

Tumor interstitial fluid pressure Head and neck cancer Radiotherapy