갑상선 결절의 Ki67과 p27 발현도에 대한 분석

• 영문명: Significance of Ki67 and p27 Reactivities in Various Thyroid Disorders
• 발행기관: 대한두경부종양학회
• 저자명: 박정수(Cheong Soo Park) 정웅윤(Woung Youn Chung) 장항석(Hang Seok Chang) 이미경(Mi Kyung Lee)
• 간행물 정보: 『대한두경부종양학회지』제15권 제1호, 3~8쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1999.05.30

영문 초록

Objective: The expression of Ki67, a proliferation marker, and p27, a cyclin dependent kinases(CDKs) inhibitor, has been studied in various human neoplasms. This study was carried out to determine whether these markers are useful in distinguishing benign from malignant lesions of the thyroid or predicting biologic behavior of malignant lesions. Material and Methods: Using immunohistochemical techniques with monoclonal antibodies to Ki67 and p27, we analyzed the expression of Ki67 and p27 in various thyroid disorders(25 follicular adenomas, 47 follicular carcinomas, 16 papillary carcinomas, 20 adenomatous goiters and 40 normal thyroid tissues). The labeling indices(LIs) were determined by counting cells expressing these markers in 1000 cells per immunostained slide. Results: Neoplastic thyroid diseases showed higher expression of Ki67 and lower expression of p27 than non-neoplastic diseases(p LI=55.4±5.7) and follicular carcinomas( LI=23.2±10.2). There was, however, no significant correlation between the degree of Ki67 and p27labeling indices and types of carcinoma or clinical aggressiveness of diseases. Conclusion: The degree of Ki67 and p27 expression was useful in distinguishing between benign from malignant thyroid lesions, particulary between follicular adenoma and follicular carcinoma, but was not directly proportional to the tumor aggressiveness.

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대상 및 방법

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키워드

Ki67 p27 Thyroid disorders