양안 각막이식에서 먼저 수술한 눈과 나중에 수술한 눈의 이식거부반응의 비교

• 영문명: Comparison of Graft Rejection of First Eyes and Second Eyes after Bilateral Penetrating Keratoplasty
• 발행기관: 대한안과학회
• 저자명: 황호식 김수영 김만수,Ho Sik Hwang, M.D., Su Young Kim, M.D., Man Soo Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number9, 1189~1195쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.09.30

영문 초록

Purpose: To compare graft rejection of the first and second eyes after bilateral penetrating keratoplasty. Methods: We performed a retrospective review of the cases of 16 patients who underwent bilateral penetrating keratoplasty. Nonparametric Kaplan-Meier survival analysis was used to account for variable follow-up among patients. Results: The mean age of the 16 patients (12 M, 4 F) was 39.1 years. Mean follow-up was 89.8 months after surgery in the first eye and 42.8 months after surgery in the second eye. The average time interval between surgery on the first and second eyes was 47.0 months. The indications for surgery were keratoconus (37.5%), corneal dystrophy (25.0%), pseudophakic bullous keratopathy (12.5%), band keratopathy (12.5%), and inflammatory corneal opacity (12.5%). Endothelial rejection occurred in five of the first eyes but was treated successfully, remaining clear until the last follow-up. Endothelial rejections were seen in five of the second eyes, two of which failed. Survival analysis of endothelial rejection showed no significant difference between the first and second eyes; however, survival analysis of the graft failure showed a decreased survival rate of the second eyes compared with that of the first eyes. The best corrected visual acuity at the last follow-up of the second eyes seemed to be worse than that of the first eyes. Conclusions: Survival analysis of the endothelial rejections showed no significant difference between the first and second eyes. Survival analysis of the graft failure showed decreased survival rate of the second eyes. At the last follow-up the best corrected visual acuity of the second eyes appeared to be worse than that of the first eyes.

키워드

Bilateral penetrating keratoplasty, Corneal graft failure, Endothelial rejection