수포각막병증에서 양막 이식술의 효용성

• 영문명: The Efficacy of Amniotic Membrane Graft in the Treatment of Symptomatic Bullous Keratopathy
• 발행기관: 대한안과학회
• 저자명: 박정현 정진욱 위원량 이진학 김미금 이재림,Jung Hyun Park, M.D., Jin Wook Jeoung, M.D., Won Ryang Wee, M.D., Ph.D.,, Jin Hak Lee, M.D. Ph.D.,, Mee Kum Kim, M.D., Ph.D.,, Jae Lim Lee, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number8, 1036~1040쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.08.31

영문 초록

Purpose: To evaluate the efficacy of amniotic membrane (AM) transplantation in symptomatic bullous keratopathy using cryo-preserved or lyophilized AM. Methods: Eight bullous keratopathic patients, who experienced intractable pain despite medication and the application of a therapeutic lens, underwent permanent AM transplantation with 5 cryo-preserved and 3 lyophilized AMs following removal of epithelium using a trephine. The time to re-epithelization and the subsidence of pain were evaluated retrospectively. Results: Mean follow-up was 252±171.0 days. Pain relief and re-epithelization were obtained in all eight patients. The times to complete relief of pain was 32.2±22.7 days in patients with cryo-preserved AM transplantations (n=5) and 22.0±18.0 days in those with lyophilized AM transplantations (n=3) (p=0.549, Mann-Whitney U test). Respective times to re-epithelization were 25.4±20.7 days and 23.0±25.2 days (p=0.297). There were no significant differences in the diameter of transplanted AMs between the two groups (7.6±0.2 vs. 7.3±0.3 mm, p=0.172). Conclusions: Permanent AM transplantation effectively reduced the intractable pain caused by epithelial bulla. Whether the AM was cryo-preserved or lyophilized did not affect the efficacy of the treatment.

키워드

Amniotic membrane transplantation, Bullous keratophathy, Epithelization, Preservation