갑상선 종양에서 Heat Shock Protein70과 Heat Shock Protein90의 발현 양상

• 영문명: Expression of Heat Shock Proteins hsp70 and hsp90 in Thyroid Neoplasm
• 발행기관: 대한내분비외과학회
• 저자명: 최진욱 김진영 박철영¹ 오기원¹ 임성희¹ 박성우¹ 조현득² 이명준³ 김이수 Jin Wook Choi M.D. Jin Yong Kim Cheol Young Park M.D.¹ Ki Won Oh M.D.¹ Sung Hee Ihm M.D.¹ Sung Woo Park M.D.¹ Hyun Deuk Cho M.D.² Myung Hoon Lee M.D.³ and Lee Su Kim M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』4권2호, 79~84쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2004.12.30

영문 초록

Purpose: Heat shock proteins (hsps) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of hsps in neoplasia has been implicated in the regulation of cell signaling pathway such as cell survival and apoptosis. This study aimed to determine whether hsps expression in various thyroid neoplasia are significant and to identify the possibility as a therapeutic molecular target. Methods: We examined the expression of the hsp70 and hsp90 on tissue section from 53 thyroid tissues (16 normal tissues; 11 nodular hyperplasia; 12 follicular adenomas; 14 papillary carcinomas) using immunohistochemistry. Hsps expression was scored according to the percentage of positively stained cells (grade 0 to grade III). Results: For hsp70, all of the 53 tissues showed over- expression. 100% (16/16) of normal thyroid tissue and 87.0% (20/23) of benign tissue were categorized as grade I or II. In comparison, the carcinoma tissues showed expression in 64.3% with grade III. For hsp90, almost of normal thyroid tissue and benign tumors showed no expression (87.5% in normal tissues, 91.3% in benign tumors). However, all of carcinoma tissues showed expression and 78.6% (11/14) of carcinoma were in grade II or III. Conclusion: In current study, the pattern of expression for hsp70 and hsp90 in normal, benign, malignant thyroid tissues suggests that heat shock proteins might have some role in tumorigenesis in thyroid. Since there have been no reports on heat shock proteins and thyroid, further study is necessary and could give us clinically significant clue for diagnosis and treatment. (Korean J Endocrine Surg 2004; 4:79-84)

키워드

Heat shock proteins, 갑상선종양, hsp70, hsp90,Thyroid, Heat shock proteins, hsp70, hsp90