원발성 부갑상선 기능항진증

• 영문명: Primary Hyperparathyroidism
• 발행기관: 대한내분비외과학회
• 저자명: 이기문 노동영 최국진 윤여규 오승근 Gee Mun Lee M.D. Dong Young Noh M.D. Kuk Jin Choe M.D. Yeo Kyu Youn M.D. and Seung Keun Oh M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』3권1호, 7~14쪽, 전체 8쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2003.04.30

영문 초록

Purpose: Primary hyperparathyroidism is the most frequent cause of hypercalcemia and due to the routine examination of serum calcium levels, the number of patients with primary hyperparathyrodism has increased. Methods: We reviewed sixty patients treated by surgery over the 20-year period at the Department of Surgery, Seoul National University Hospital and retrospectively analyzed both the clinicopathologic and bio-chemcal features of the presented cases and the effective methods of treatment and diagnosis retrospectively. Results: The study group consists of 60 patients with primary hyperparathyroidism comprised of 18 males and 42 females. The most common presenting clinical manifestations were associated with bone pain in 38 (63%), and recurrent urinary stone in 27 (45%) patients; And 11 patients were asymptomatic. All patients showed hypercalcemia and the serum parathyroid hormone (PTH) level was elevated in all 49 patients after 1992. A preopeative localization study was performed with ultrasonography (USG), computed tomography (CT), Thallium-Technecium (Tl-Tc) substraction scan and Methoxylisobutyl isonitrile (MIBI) scan. Positive localization was made in 71%, 71%, 77% and 71% respectively. Histopathologic findings revealed solitary adenoma in 56 patients and carcinoma in 4 patients. Transient hypocalcemia following surgery occurred in 50 patients and they were treated with calcium. There were no recurrent cases with the exception of one who displayed carcinoma. Conclusion: In this study, most of the patients were discovered with an advanced clinical and biochemical status but the number of the asymptomatic patients is increasing. Through an accurate preoperative localization, they were successfully treated with parathyroidectomy without major complications. (Korean J Endocrine Surg 2003;3:7-14)

키워드

원발성 부갑상선 기능항진증, 부갑상선 절제술, 부갑상선 호르몬,Primary hyperparathyroidism, Parathyroidectomy, Parathyroid hormone